Piperazine Anhydrous is a highly versatile, cyclic organic compound widely used as an essential intermediate in the pharmaceutical, polymer, and chemical manufacturing industries.
Piperazine Anhydrous CAS 110-85-0
Description
- CAS: 110-85-0
- Synonyms: Hexahydropyrazine, Diethylenediamine, 1,4-Diazacyclohexane
- Einecs: 203-808-3
- Molecular Formula: C₄H₁₀N₂
- Grade: Industrial Grade / Pharmaceutical Grade
- Package: As required
Details
Chemical Reactions
Salt Formation: Reacts readily with organic and inorganic acids to form stable salts (e.g., reacting with citric acid to form Piperazine Citrate).
Alkylation: Reacts with alkylating agents to form N-alkyl and N,N’-dialkyl derivatives, which are crucial in pharmaceutical synthesis.
Carbon Dioxide Absorption: Reacts with CO₂ in the atmosphere to form carbonates, requiring strictly sealed storage environments.
Specifications
| Parameter | Specification |
| Appearance | White to slightly yellow crystalline flakes or powder |
| Assay (Purity) | ≥ 99.0% |
| Melting Point | 109°C – 112°C |
| Volatility | ≤ 1.0% |
| Ash Content | ≤ 0.1% |
| Solubility | Highly soluble in water and ethanol; insoluble in ether |
| Thermal Stability | Stable under recommended storage; Flash point ~65°C |
Data Sheet Download
Applications
Pharmaceutical Intermediates: Used to synthesize a variety of active pharmaceutical ingredients (APIs), particularly anthelmintics (dewormers), antihistamines, and antipsychotic drugs. Role: Acts as the core structural backbone (pharmacophore) for these medications.
Polymers and Resins: Applied in the production of polyamides, polyurethanes, and epoxy curing agents. Role: Functions as a highly effective chain extender and curing accelerator.
Gas Treatment (Desulfurization): Added to gas-sweetening amine systems. Role: Acts as a kinetic promoter that significantly speeds up the absorption of CO₂ and H₂S from natural gas.
Storage
Moisture Control: Must be kept in a dry environment. The product is highly hygroscopic and will degrade or clump if exposed to ambient humidity.
Temperature: Store in a cool, well-ventilated area away from direct sunlight and heat sources.
Container Sealing: Keep containers tightly closed when not in use to prevent reactions with airborne carbon dioxide and moisture.
Incompatibilities: Store away from strong oxidizing agents, strong acids, and dicyanofurazan.
Handling & Usage Precautions
Personal Protective Equipment (PPE): Always wear chemical-resistant gloves, safety goggles, and protective clothing. A dust mask or respirator is highly recommended to prevent inhalation.
Ventilation: Handle in a well-ventilated area or under a chemical fume hood to minimize exposure to dust and vapors.
First Aid: Piperazine can cause severe skin burns and eye damage. In case of contact, immediately flush skin or eyes with plenty of water for at least 15 minutes and seek medical attention.
Hygiene: Wash hands and face thoroughly after handling. Do not eat, drink, or smoke in the working area.
Formulations
- Anthelmintic Formulations: Formulated into tablets or syrups for veterinary and human medicine. Role: Paralyzes parasitic worms by blocking acetylcholine at the myoneural junction, allowing the host to expel them naturally.
- Activated MDEA Blends: Formulated with Methyldiethanolamine (MDEA) in the petrochemical industry. Role: Piperazine accelerates the chemical reaction rate between the amine solution and acid gases, boosting the overall efficiency of the gas-sweetening process.
Packaging
- 20 kg fiber drum or carton box, lined with PE bag.
- Customized packaging available upon request.
Safety & Compliance
| Compliance / Safety Metric | Status / Description |
| SDS/MSDS | Available |
| GHS Classification | Danger (Corrosive, Sensitizer, Reprotoxic) |
| UN No. | 1090 |
| Transport Class | 3 |
| Hazard Statements | Causes severe skin burns and eye damage; May cause allergic skin reaction; Suspected of damaging fertility. |
| Labeling and Packaging Compliance | Fully compliant with international GHS and transport regulations |
| COA / TDS | Available Upon Request |
| Batch Traceability | Complete lot-to-lot traceability system maintained |
FAQ
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Q: How to get more information about the product?A: You can contact us via email at info@zhpmchem.com or WhatsApp at +8618321309391 for more information about our products and company.
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Q: Does the product meet our requirements regarding formulation, equipment, and processing?A: Yes, we will adjust the product formulation to your specific needs, ensuring it meets your processing requirements.
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Q: What is the difference between Piperazine Anhydrous and Piperazine Hexahydrate?A: The primary difference is moisture content. Piperazine Anhydrous contains strictly no water (purity ≥ 99%), making it ideal for moisture-sensitive chemical synthesis. Piperazine Hexahydrate contains six water molecules and has a lower melting point (44°C).
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Q: Is Piperazine Anhydrous prone to caking?A: Yes. Because it is highly deliquescent, it absorbs moisture from the air rapidly, which can lead to caking or clumping. It must remain in its tightly sealed, PE-lined packaging until immediately before use.
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Q: Can this grade be used directly in human food or medicine?A: No. While it is used to manufacture Pharmaceutical Grade derivatives (like piperazine citrate), this raw chemical is an industrial intermediate and must undergo further processing, synthesis, and purification before therapeutic use.
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Q: How do I handle a spill of Piperazine Anhydrous?A: Put on appropriate PPE. Sweep or shovel the spilled solid into a designated, sealed chemical waste container, avoiding dust generation. Do not flush raw chemical down the drain; dispose of it according to local environmental regulations.